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Introduction to PV-9 Crystals

PV-9, also known as α-POP (alpha-pyrrolidinooctanophenone), is a synthetic cathinone belonging to the pyrovalerone class of compounds. It is the higher homologue of α-PVP, distinguished by an extended α-carbon side chain containing eight carbon atoms—three carbons longer than its well-known analogue . This structural elongation significantly alters its pharmacological and toxicological profile, making it a compound of distinct research interest.

Within the research community, PV-9 is primarily utilized as a certified reference standard for forensic and toxicological applications, including the identification and quantification of novel psychoactive substances in biological samples. It has been detected in fatal poisoning cases, with postmortem blood concentrations of 0.743 µg/mL documented in polydrug intoxications . At 4mmcchems, we supply premium-grade PV-9 Crystals to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: PV-9 Crystals (α-POP; α-Pyrrolidinooctanophenone)

Synonyms: 1-Phenyl-2-(pyrrolidin-1-yl)octan-1-one, α-POP

CAS Number: 2749897-19-4 (hydrochloride)

Molecular Formula: C₁₈H₂₇NO

Molecular Weight: 273.41 g/mol (free base)

Purity: ≥ 98% (verified by third-party HPLC/GC-MS testing)

Form: Crystalline solid

Storage: -20°C for long-term stability

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

PV-9 belongs to the α-pyrrolidinophenone class of synthetic cathinones. The primary mechanism of action for this compound class is inhibition of the dopamine transporter (DAT) and norepinephrine transporter (NET), preventing the reuptake of these neurotransmitters from the synaptic cleft .

Key Pharmacological Data

Research demonstrates that PV-9 produces significantly lower in vivo psychostimulant potency compared to α-PVP. In controlled mouse studies, PV-9 at 10 mg/kg elevated striatal extracellular dopamine to approximately 430% of baseline, whereas α-PVP at the same dose reached approximately 630%—a 1.5-fold difference . Horizontal locomotor stimulation was also significantly more pronounced for α-PVP than for PV-9 .

Distinct Cytotoxicity Profile

Importantly, despite lower psychostimulant potency, PV-9 demonstrates markedly greater cytotoxicity than shorter-chain analogues. In LDH release assays, PV-9 at 500 µM caused approximately 25-30% LDH release, indicating substantial plasma membrane permeabilization, whereas α-PVP produced less than 10% LDH release at the same concentration . This suggests a compound-specific mechanism of toxicity involving membrane disruption, distinct from other α-pyrrolidinophenones .

Metabolic Pathways

PV-9 undergoes extensive metabolism, producing 16 metabolites identified in human urine, including lactam, keto group, and carboxylic acid metabolites in addition to hydroxy metabolites . The longer alkyl chain of PV-9 directly influences the formation of these unique oxidative metabolites, which has direct implications for analytical method development and toxicological interpretation .

Why Choose 4mmcchems?

1. Uncompromising Quality

We source our PV-9 Crystals from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold required for analytical reference materials .

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

4mmcchems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: We have optimized shipping routes to ensure timely delivery to countries including Germany, France, the United Kingdom, Spain, Italy, the Netherlands, Switzerland, Norway, and more.

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making 4mmcchems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

PV-9 is a regulated substance in many jurisdictions. It has been associated with fatal poisoning cases, with documented postmortem blood concentrations as high as 0.743 µg/mL in polydrug intoxications . The compound is subject to control under various national and international frameworks.

Important Considerations for Researchers:

• Controlled Status: PV-9 is subject to regulation in many countries. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. Given its documented cytotoxicity and membrane disruption properties, appropriate personal protective equipment is recommended .

Shipping Information: Worldwide Delivery

4mmcchems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance.

How to Order

1. Browse Our Catalog: Select PV-9 Crystals and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is PV-9 used for in research?

A: PV-9 is used as an analytical reference standard for forensic and toxicological applications, including identification and quantification in biological samples, transporter binding assays, and structure-activity relationship studies .

Q: Is PV-9 legal to purchase?

A: PV-9 is subject to regulation in many jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

Q: How should PV-9 be stored?

A: Store at -20°C for long-term stability. Protect from light and moisture .

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries. Please refer to our shipping policy for more details.